Is Top Up Tonic safe to take with SSRIs? March 19, 2021 16:57 Updated Yes it is! There are no known interactions with any SSRIs. Related articles I already take a daily probiotic. Does Top Up Tonic have enough to replace it? Does the vitamin C or zinc in Top Up Tonic make oral birth control less effective? I already take a multivitamin. Would it be harmful to take both? Is it safe for women using the Nuvaring and other types of hormonal birth control? How can Top Up Tonic help with birth control side effects?